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KMID : 0613820080180040580
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Journal of Life Science
2008 Volume.18 No. 4 p.580 ~ p.584
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Immunohistochemical Expression of Methyltransferase (MGMT) in Korean Patients with Non-Small Cell Lung Cancer
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Lee Kyung-Eun
Hong Young-Seoub
Choi Pill-Jo
Roh Mee-Sook
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Abstract
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O6-methylguanine-DNA methyltransferase (MGMT) is a DNA repair protein that protects cells against the carcinogenic effects of alkylating agents. The loss of MGMT expression was commonly known due to hypermethylation of CpG islands in its promoter region. We evaluated the expression of MGMT by immunohistochemistry in order to examine the relationship between loss of MGMT expression and clinicopathological characteristics in 74 Korean patients with non-small cell lung cancers. Loss of MGMT was detected in 25 (33.8%) of 74 cases. The loss of MGMT expression was frequently seen in the adenocarcinoma than in the squamous cell carcinoma (p=0.021). However, there was no significant differences between loss of MGMT expression and other clinicopathological characteristics, including age, gender, smoking status, tumor size, tumor T stage, and lymph node metastasis (p>0.05). In conclusion, loss of MGMT expression was related with the histologic type of lung cancer. Further methylation study of MGMT promoter is needed to evaluate the relationships with immunohistochemical expression of MGMT and to clarify the role of MGMT in lung cancer.
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KEYWORD
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O6-methylguanine-DNA, methyltransferase, non-small cell lung cancer, immunohistochemistry
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